Bugs as modulators of intestinal barrier and outcome

Bugs as modulators of intestinal barrier and outcome

 

In 2007, we discovered that gut microbes were involved in the onset of inflammation (metabolic endotoxemia) and gut barrier dysfunction in obese/diabetic subjects. In a series of studies, we revealed that treating obese/diabetic mice and humans with Akkermansia muciniphila improved insulin sensitivity, metabolic endotoxemia and gut barrier via different mechanisms. We will discuss the beneficial effects of A. muciniphila as well as the newly isolated bacterium: Dysosmobacter welbionis.