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FEEDING THE MICROBIOTA

CANCER IMMUNITY AND MICROBIOTA

4th Symposium GE-VD

7th February 2019  |  Geneva University Hospitals (HUG)

This yearly symposium aims at highlighting the impact of nutrition on microbiota and the subsequent potential for prevention and treatment of diseases.

Recent studies implicate the microbiota of the digestive tract in the development and progression of diseases. Thus, there is a growing interest to modulate the microbiota to improve health state. It is recognized that the microbiota of each person is different. Part of theses differences are related to food intake.

Although the impact of each food component on microbiota is yet unclear, it opens new areas of research and potential treatment for diseases. It suggests that diseases may be modulated by nutrition and also paves the way for personnalized medicine.

Microbiota refers to all microorganisms present in the human organism, whether bacteria, viruses, parasites or fungi.

It may be located in the digestive tract (oral, gut), but also on the skin and on any interface between the human body and the external world.

These micro-organisms likely interact with our immune and neurologic systems and appear to be linked with potential diseases.

ORGANISERS

 

Jacques Schrenzel

Prof. Jacques Schrenzel (MD) is board-certified in internal medicine, in infectious diseases and in clinical microbiology. He is the co-founder of the Center of Excellence in Bacteriology at the University of Geneva (CEBUG). He is in charge of the bacteriological laboratory and the genomic research laboratory of Geneva University Hospitals (www.genomic.ch). He is recognized for his work on bioinformatics, metagenomics, microarrays and next-generation sequencing techniques, with the common objective to translate new techniques for patient care.

 

Laurence Genton Graf

Prof. Laurence Genton (MD) is board-certified in internal medicine and working since over 20 years in clinical nutrition. She is president elect of the Swiss Society of Clinical Nutrition from 2014 until 2018 and member of the education committee of the European Society for Clinical Nutrition and Metabolism since 2017.

Her research work focuses on the link between nutrition state and energy expenditure and gut microbiota, and the impact of body composition on outcome.

  • Thursday07-02-2019
13.00

Welcome speech

13.10

Integration of gut microbiota to clinical specialities : Prof. Claude Pichard (HUG)

While stool transplantation has drawned medical attention and has been rather successfully applied in a few chronic diseases, it seems difficult to apply during critical illnesses (ICU). Microbiome manipulation in  ICU patients requires a novel approach.   During the early phase of acute illness, the goal would be the maintenance of a physiologic mass of beneficial bacteria and yeasts by ...


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Prof. Claude Pichard, MD, PhD
Geneva

Moderators : Prof. Claude Pichard (HUG), Dr. Valérie Dutoit (HUG)

Moderators are interested in introducing this subject to stimulate discussion around microbiota with some provocative interchange in perspective.


13.15

Gut microbiota modulation through pre-and probiotics : Prof. Laure Bindels

Cancer cachexia is a complex multi-organ syndrome characterized by weight loss, muscle atrophy and fat mass loss. With a prevalence of 1 million people in Europe and only limited therapeutic options, there is a high medical need for new approaches to treat cachexia. In this context, we started a few years ago studying the therapeutic interest of modulating the gut ...


Prof. Laure B. Bindels, PhD.
Belgium
13.50

Gut microbiota and its role in cancer treatment : Prof. François Giringhelli

Discoveries made in the past recent years indicate that the composition of the intestinal microbiota has a major influence on the effectiveness of anticancer immunogenic chemotherapies and immunotherapies like inhibitors that target cytotoxic T lymphocyte protein 4 (CTLA-4) or the programmed cell death protein 1 (PD-1)-programmed cell death 1 ligand 1 (PD-L1) axis. I will highlight how some bacteria, such ...


Prof. François Giringhelli
France

Moderators : Prof. François Pralong (La Tour), Prof. Laurence Genton (HUG)

Moderators are interested in introducing this subject to stimulate discussion around microbiota with some provocative interchange in perspective.


14.25

Medical aspect of fecal transplantation : Dr. Tatiana Galperine

With at least 8 randomized controlled trials, Fecal microbiota transplantation (FMT) has emerged as an effective and safe therapy for multiple recurrent C. difficile infection  (CDI) (> 3 episodes). The European Society of Clinical Microbiology and Infectious diseases (ESCMID) and the Infectious Diseases Society of America (IDSA) have both included FMT has an option for recurrent episodes in published guidelines. ...


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Dr. Tatiana Galperine
Switzerland
14.25

Patient’s experience of fecal transplantation : Mrs Lasserre Rouiller


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Mme Lasserre Rouiller
Switzerland
14.25

Technical aspects of gut microbiota analysis : Prof. Jacques Schrenzel (HUG)


Prof. Jacques Schrenzel (MD)
Geneva
15.10

Coffee break

Let’s enjoy a break and get ready for the next session.


Moderators : Dr. Thibaud Koessler (HUG), Prof. Gilbert Greub (CHUV)

Moderators are proud to stimulate the discussion around the microbiota. Some interesting interchange in perspective !


15.45

Immunology of gut barrier in colo-rectal cancer : Prof. Alexander Moschen


Dr. Alexander Moschen
Austria
16.20

Gut microbiota in hepatic cancer : Prof. Christian Toso (HUG)

Hepatocellular carcinoma (HCC) is the fifth most frequent cancer in men and the ninth most frequent cancer in women (http://gco.iarc.fr/today/home). It is associated with a high mortality, representing the second cause of cancer-related death worldwide. In Switzerland, 780 individuals are newly diagnosed with HCC every year (https://www.liguecancer.ch/). Recent observations suggest that the gut-liver axis have an impact on HCC: (1) ...


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Dr. Christian Toso
Geneva
16.55

Conclusive speech : Prof. Jacques Schrenzel (HUG)

Prof. Jacques Schrenzel closes the conference in wrapping up  the main messages given during Nutrition and Microbiota.


Prof. Jacques Schrenzel (MD)
Geneva
17.00

Aperitif

Let’s have a drink together ! We are ready for networking.


Free Registration

Please register to participate to the 4th symposium on nutrition and microbiota. Please print the ticket and bring it with you. Registration will allow you to have access to the presentations at the end of the symposium and to get the certificate of presence and the training credits. Click on the button !

Registration

Register for free to participate to the symposium on the topic of cancer, immunity and microbiota. Free entrance but compulsory registration

Speakers

Once again, microbiota specialists are participating at the high-quality symposium on nutrition and microbiota. Meet with them !

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Mme Lasserre Rouiller
Switzerland

How FMT saved a Swiss patient’s life ill with ulcerative ...

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Dr. Christian Toso
Geneva

Divisions of Abdominal and Transplantation Surgery, Department of Surgery, and ...

Prof. Laure B. Bindels, PhD.
Belgium

Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.

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Prof. Claude Pichard, MD, PhD
Geneva

Claude PICHARD, MD, PhD is Professor of nutrition at the ...

Prof. Jacques Schrenzel (MD)
Geneva

Prof. Jacques Schrenzel (MD) is board-certified in internal medicine, in ...

Prof. Laurence Genton (MD)
Geneva

Physician in nutrition at the Geneva University Hospital, Switzerland. Specialist ...

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Moderators

Moderators are interested in introducing this subject to stimulate discussion ...

Sponsors

We are grateful to the corporate and institutional sponsors that support the symposium. If you wish to participate to this growing journey, please contact us to discuss about the sponsorship opportunities.

Partners

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logo-Université-de-Lausanne-partner-nutrition-microbiota

This event is supported by the Swiss Society for Clinical Nutrition (SSNC/GESKES).

Post-gradual credits will be requested yearly for internal general medicine, gastro-enterology, infectious diseases, endocrinology-diabetology and oncology, as well as the ASDD/SVDE.

Location

Auditoire Marcel Jenny

Auditoire Marcel Jenny – Geneva University Hospitals (HUG) Principal
Entry, Floor 0, Rue Gabrielle-Perret-Gentil 4, 1205 Genève

Because of limited parking availability at the HUG, we recommend to use public transportation

 

To go to HUG by public transport you can take tram 12, 14 or 18 and stop at Augustins. You can also take the bus 1, 5 and 7 bus station “Hôpital” or the bus 35 bus station Augustins. For more details please look at “useful informations”

Useful informations

Plane

Among European cities, Geneva is one of the best connected by low-cost airlines. Altogether, there are more than a hundred direct daily flights landing in Geneva connecting it to European capitals and important cities such as Berlin, Frankfurt, London, Madrid and Lisbon.

Geneva’s international airport is located in the NW of town, 4 km from Geneva city center and very well connected to the city center.

For further information about airport network, please visit the website of GVA Airport.

If you arrive at Zürich Airport, you can reach Geneva either by train (approx. 3 hours) or book a domestic flight (approx. 45 min).

Flight information: 0900 57 15 00

Bus information :  https://www.tpg.ch/

 

To reach the HUG from airport:

BY BUS

  • Bus line No 5, direction Thônex-Vallard: travel time approximately 35 minutes (19 stops) get off at stop Lombard and then walk 260 m to the entry of HUG.
  • Frequency : approx. every 10 minutes.
  • Price : You can pick up a free ticket for public transport from the machine in the baggage collection area at the Arrival level. This unireso ticket, offered by Genève Aéroport, allows you to use public transport in Geneva free for a period of 80 minutes.

BY TRAIN

  • Train SBB (IC1/ IC5/ IR15 or IR90): travel time approximately: 30 minutes (1 stop); get off at stop Gare Cornavin and then take bus 1 direction: Hôpital Trois-Chêne get off at stop Lombard .
  • Frequency: approx. every 10 minutes.
  • Price: approx. CHF 8.00

BY TAXI

  • Taxi to the HUG will take about 20/30 minutes, and cost approx. CHF 58.00

Train

Switzerland’s rail network meets the highest European standards. Thanks to its central location, Geneva is easily accessible by train, e.g. Paris (3h30min) or Milan (3h50min). Cornavin station is the central station in the heart of the city with a non-stop connection to Geneva airport (6 min).

Switzerland’s national rail network keeps Geneva connected to the rest of Switzerland as well as Europe. For further information, please consult the SBB website.

Car

Thanks to the highly efficient road network throughout Switzerland and Europe, Geneva is easily accessible by car. Arriving from the direction of Zürich you can reach Geneva via the A1 motorway.

Please note that a motorway sticker, “vignette”, is compulsory to drive on motorways and semi-highways. Valid for 1 year, the vignette costs CHF 40.00 and is on sale at post offices, petrol stations and customs offices. Read more.

Zürich: 279 km
Paris: 541 km
Munich: 588 km

Public transport

TO REACH THE HUG BY BUS

To go to HUG by public transport you can take tram 12, 14 or 18 and stop at Augustins. You can also take the bus 1, 5 and 7 bus station “Hôpital” or the bus 35 bus station Augustins.

Unireso stands for a group of 7 transportation companies in Geneva and its region. The circuits represent more than 450 kilometers in Geneva and into the near vicinities of the canton Vaud and France. With one ticket, you have the possibility to benefit from the whole network (buses, trams, boats, etc.).

Unireso tickets and day passes must be purchased before boarding the vehicle from one of the automatic vending machines located at the stops.

A valid ticket must always be carried during the journey and presented in the event of a control. Fares are CHF 3.50 for one hour public transport in Geneva, or CHF 2.00 for a “saut de puce” (max. 3 stops or 1 transfer by boat, “Mouettes Genevoises”).

Unireso stands for a group As of January 1st 2007, all visitors staying at a hotel, youth hostel or camping site in Geneva can benefit from the Geneva Transport Card, available free of charge.

This personal and non-transferable pass is established upon the visitor’s check-in at the hotel of his choice, enabling its holder to use the entire Geneva public transport network without restriction network (UNIRESO: bus and tram (TPG), train (SBB) and boats (“Mouettes Genevoises”). It is valid for the entire duration of the stay including the departure day. Furthermore, on the arrival floor at the airport, visitors can retrieve their free 80-minute ticket from a ticket machine in the luggage retrieval hall.

For more information please visit tpg website.

Bike

You can also borrow bicycles for FREE! Enjoy getting around on two wheels and pedal throughout the city during your stay.

Find a borrowing site HERE

European Low-Cost Hub

Among European cities, Geneva is one of the best connected by low-cost airlines. Altogether, there are more than a hundred direct daily flights landing in Geneva. It’s so easy to take a city break!

A ‘City Pass’ for a budget price

The Geneva Pass is a true Open up! With more than 47 tourist attractions and activities, free or at preferential rates, including a few gifts. Get all of Geneva for a budget price!

More about the Geneva Pass

Hostels

In Geneva city and around Geneva you will be able to find several hostels for low prices. Please discover here the Geneva tourism list.

Free public transport

Unireso stands for a group As of January 1st 2007, all visitors staying at a hotel, youth hostel or camping site in Geneva can benefit from the Geneva Transport Card, available free of charge.

This personal and non-transferable pass is established upon the visitor’s check-in at the hotel of his choice, enabling its holder to use the entire Geneva public transport network without restriction network (UNIRESO: bus and tram (TPG), train (SBB) and boats (“Mouettes Genevoises”). It is valid for the entire duration of the stay including the departure day. Furthermore, on the arrival floor at the airport, visitors can retrieve their free 80-minute ticket from a ticket machine in the luggage retrieval hall.

For more information please visit the TPG website.

Geneva is a truly international city and its great history and development blends the advantages of a small city with the services and possibilities of a large metropolitan area. Internationally renown as a conference city, Geneva is an ideal location due to its central setting at the heart of Europe and its multicultural flair, being home to important international organizations such as the United Nations, the World Health Organization or the International Labour Organization.

Combining exceptional history, refined cuisine, entertainment and culture, Geneva offers a great variety of activities. Every year in the summer, the famous Geneva Festival attracts numerous visitors from all over the world.

Altitude

374m (1,227ft) above sea level

Climate

Geneva has a temperate climate, temperatures range from -2 to +5°C (28 to 41°F) in winter and 12 to 28°C (54 to 82°F) in summer . The annual rainfall is aproximately 1 000 mm/year (including 32cm of snow) The average temperature in June is 18°C.

Currency

Swiss Franc (CHF or SFr) Average rate: 1 Euro = CHF 1.10. The exchange rate for the Euro and the Swiss Franc is not officially fixed and is subject to daily market fluctuations. Conversion rates are available at foreign exchange offices, banks and in newspapers.

Driving

In town speed is limited to 50 km/h or 30 km/h in some areas, on national roads beyond city limits 80 km/h, and on motorways 120 km/h. A motorway sticker, « vignette », is compulsory on highways and semi-highways. It is valid for 1 year and available at the price of CHF 40.00 – at post offices and customs offices. Wearing seat belts, both in the front and in the back of a vehicle is compulsory.

Electricity

220 volts. Plug type J, socket converters are available in local shops and CICG (CHF 15.00).

Public Transport

The public transport network in Geneva covers perfectly the entire city. It is reliable and used by the majority of the population. All visitors staying at a hotel in Geneva can benefit from this personal and non-transferable pass with free of charge.

Visit Geneva

Geneva is an amazing city to visit, with its gardens, manufacturers and lake views you will enjoy your stay.
A city pass will offer you preferential fares, free entries, and gifts. Valid for 24, 48 or 72 hours it is your “open Sesame” to museums, cruises, visits, tours and many other surprises. For more information about the city tours and Geneva pass, please click here.

Language

There are four official languages in Switzerland: French, German, Italian and Romansh.
The official language in the western part of Switzerland and therefore also in Geneva is French. Due to its international character English and also German are often spoken in Geneva.

Population

City and Canton: 476 006 inhabitants.

City of Geneva: 194 458 inhabitants.

Tipping

Prices in hotels, restaurants, taxi fares etc. include taxes and service. A tip, therefore, is not indispensable, but justified for good service.

Airport access

The Geneva Airport is largely accessible to persons with disabilities. The airport is well connected by public transport. There are regular trains connecting the airport to Gare Cornavin (the train station). Bus routes 5 and 10 connect with the airport. For more information other bus routes, you can consult the Geneva Airport website.

If using public transport on arrival, you should remember to get a free public transport ticket that is valid for 80 minutes. The free ticket machine is located in the baggage claim area, just before the exit to the main arrival hall.

For persons using wheelchairs, the bus is a better option to and from the airport as the trains are usually not accessible. To use the train you are required to book special assistance at least an hour in advance for assist in boarding and getting off the train. However, no special notice is needed to use the bus. The bus stop is located at level E (Enregistrement, in French, departure level). From the arrival lounge take the lift to level E, exit out of the terminal and go toward the left for about 15 meters. Cross the road over the pedestrian crossing and you will reach the bus stop.

Accessibility in public transport

Most hotels in Geneva will give you a free transport card. This card will allow you to travel for free on bus, tram, and boat in Geneva. If you do not have a free transport card, then you should buy your ticket from the machine before you get on the bus/tram/boat. Please be aware that not all ticket machines provide change.

Most trams and buses are accessible and the Geneva transport authority is constantly replacing inaccessible vessels with accessible ones. However, on any route, if there is an inaccessible bus or tram that you encounter, then ask the driver when the next accessible bus or tram will be arriving, and she or he may call the dispatcher to find out.

While there is a button to press to indicate to the driver that a person with disabilities wishes to board, you need to indicate to the bus driver directly that you wish to board the bus. The driver will come and open the ramp so that you can enter. Let the driver know the stop where you want to get off. For the tram, while it is completely accessible, it is better to get into the carriage right behind the driver as those are indicated as accessible. Moreover, the driver can provide assistance if required.

Mobilité pour tous (Mobility for All) is a program in partnership with Geneva Public Transport service network that provides free service to enable persons with vision impairments or walking difficulties (not wheelchair users) to travel on public transport network with a guide. The guides mostly speak only French.

The service is available from Monday to Friday from 8 a.m. to 6 p.m. You need to book the assistance 48 hours in advance. Tel.: +41 22 328 1111. More details of the program are available in French on the website.

Taxi Services

Regular taxis must be reserved in advance, as they cannot be hailed in the street. Tel.: +41 22 331 4133.

UBER service is also readily available throughout the city.

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